In human dermal fibroblast cultures and an ex-vivo skin explant model, the study reported that combining GHK-Cu (copper tripeptide-1) with hyaluronic acid upregulated collagen I, IV, and VII expression, with a synergistic effect observed for collagen IV.
GHK-Cu
A copper-binding peptide often discussed in skin research. An ingredient study is not evidence for every finished cosmetic.
The short version
A copper-binding peptide often discussed in skin research. An ingredient study is not evidence for every finished cosmetic.
What does the research tell us?
A result in a cell or an animal does not establish the same result in people. Read the study design, the measurements, and the limitations before drawing a conclusion.
What remains uncertain?
The research question, the formulation, and the population all matter. This page is a starting point for understanding the literature, not a complete assessment of benefits or risks.
Identity & technical details
For readers who want the reference details.
- Name
- GHK-Cu
- Also known as
- Copper peptide, Glycyl-L-histidyl-L-lysine copper
- Topic
- Recovery & skin
- CAS
- 89030-95-5
- Amino-acid sequence
- GHK
Explore the sources
Open a source to read its methods and limitations. Published titles are kept in their original language.
In an irradiated rat dorsal-flap model, a topical glycyl-histidyl-lysine-copper (GHK-Cu) gel was compared with a control ointment, with flaps assessed for ischemic area and immunohistochemical markers of vascular endothelium (caveolin-1) and VEGF expression in fibroblasts.
This review surveys reported biological actions attributed to the GHK (and GHK-Cu) peptide, including reported stimulation of collagen, elastin, and glycosaminoglycan synthesis and effects on dermal fibroblasts, interpreted alongside gene-expression data discussed by the authors.
This guide explains research. It does not recommend a treatment, product, or dose.
A laboratory arithmetic tool. It does not determine a dose for a person.
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