In a mouse study including cultured ovarian granulosa cells, Kisspeptin-10 was associated with increased granulosa-cell proliferation, ovarian follicle development, and higher serum progesterone and estradiol, reportedly acting through the PI3K/AKT/ERK signaling pathway.
Kisspeptin
A peptide involved in reproductive hormone signalling. The name covers forms with different chain lengths.
The short version
A peptide involved in reproductive hormone signalling. The name covers forms with different chain lengths.
What does the research tell us?
A result in a cell or an animal does not establish the same result in people. Read the study design, the measurements, and the limitations before drawing a conclusion.
What remains uncertain?
The research question, the formulation, and the population all matter. This page is a starting point for understanding the literature, not a complete assessment of benefits or risks.
Identity & technical details
For readers who want the reference details.
- Name
- Kisspeptin
- Also known as
- Kisspeptin-10, Metastin
- Topic
- Brain & hormones
- CAS
- 374675-21-5
- Amino-acid sequence
- YNWNSFGLRF
Explore the sources
Open a source to read its methods and limitations. Published titles are kept in their original language.
In ewe lambs tracked across the peripubertal period, plasma kisspeptin-10 and neurokinin B concentrations rose with age while dynorphin A declined; the onset of ovarian activity coincided with concurrent increases in kisspeptin-10 and neurokinin B alongside reduced dynorphin A.
In an in-vitro study of cultured anterior pituitary cells from pubescent ewes, neurokinin B was reported to increase kisspeptin-10 secretion in a dose- and time-dependent manner, whereas dynorphin A had no significant effect on its release.
This guide explains research. It does not recommend a treatment, product, or dose.
A laboratory arithmetic tool. It does not determine a dose for a person.
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