This review surveys the reported molecular aspects of the tuftsin-analogue heptapeptide Selank, summarizing described receptor interactions and proposed mechanisms underlying its anxiolytic-related activity reported in preclinical models.
Selank
A synthetic peptide related to tuftsin, studied in research on stress-related and brain signalling.
The short version
A synthetic peptide related to tuftsin, studied in research on stress-related and brain signalling.
What does the research tell us?
A result in a cell or an animal does not establish the same result in people. Read the study design, the measurements, and the limitations before drawing a conclusion.
What remains uncertain?
The research question, the formulation, and the population all matter. This page is a starting point for understanding the literature, not a complete assessment of benefits or risks.
Identity & technical details
For readers who want the reference details.
- Name
- Selank
- Also known as
- TP-7
- Topic
- Brain & hormones
- CAS
- 129954-34-3
- Amino-acid sequence
- TKPRPGP
Explore the sources
Open a source to read its methods and limitations. Published titles are kept in their original language.
In a rat model of ethanol-induced memory impairment, administration of Selank (a peptide analogue of tuftsin) was associated with changes in brain-derived neurotrophic factor (BDNF) content in the hippocampus and prefrontal cortex, alongside changes in memory-related behavioral measures reported by the investigators.
In cultured IMR-32 human neuroblastoma cells, Selank was reported to alter the expression of several genes involved in GABAergic neurotransmission relative to control conditions.
In a rat model of unpredictable chronic mild stress, the peptide Selank administered together with diazepam was associated with differences in anxiety-related behavioral measures relative to the comparator conditions tested. Findings are from a rodent behavioral paradigm only.
This guide explains research. It does not recommend a treatment, product, or dose.
A laboratory arithmetic tool. It does not determine a dose for a person.
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