In mouse models, the mitochondrial-derived peptide MOTS-c was associated with improved intrinsic skeletal-muscle mitochondrial bioenergetic health and efficiency, alongside altered reactive-oxygen-species handling, in a manner reported to depend on PGC-1α and AMPK signaling.
MOTS-c
A small peptide encoded in mitochondrial DNA, studied in questions about energy regulation and metabolism.
The short version
A small peptide encoded in mitochondrial DNA, studied in questions about energy regulation and metabolism.
What does the research tell us?
A result in a cell or an animal does not establish the same result in people. Read the study design, the measurements, and the limitations before drawing a conclusion.
What remains uncertain?
The research question, the formulation, and the population all matter. This page is a starting point for understanding the literature, not a complete assessment of benefits or risks.
Identity & technical details
For readers who want the reference details.
- Name
- MOTS-c
- Also known as
- Mitochondrial ORF of the twelve S rRNA-c
- Topic
- Metabolism
- CAS
- 1627580-64-6
- Amino-acid sequence
- MRWQEMGYIFYPRKLR
Explore the sources
Open a source to read its methods and limitations. Published titles are kept in their original language.
In a diabetic rat model, aerobic exercise and the mitochondrial-derived peptide MOTS-c, alone or combined, were associated with improved glucose and lipid profiles and reduced myocardial collagen deposition, which the authors link to suppression of the THBS1/TGF-β signaling pathway.
In a mouse model of cancer cachexia, exogenous MOTS-c was associated with partial preservation of skeletal-muscle mass without preventing overall body-weight loss, alongside modulation of FOXO signaling and partial restoration of PGC-1α expression relative to cachectic controls.
This systematic review and meta-analysis pooled reported circulating MOTS-c concentrations across metabolic states, describing significantly reduced plasma MOTS-c in diabetes and obesity in the primary analysis, and positive correlation of circulating MOTS-c with total cholesterol and LDL-c in the analyzed studies.
This guide explains research. It does not recommend a treatment, product, or dose.
A laboratory arithmetic tool. It does not determine a dose for a person.
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