In an in-vitro model using human tumor cell lines and isolated immune cell subsets, Thymosin alpha-1 was reported to modulate the transcriptional profiles of immune cells, with the most pronounced changes observed in activated CD8+ T cells.
Thymosin Alpha-1
A peptide discussed in research on immune-system signalling. Findings depend on the condition and study design.
The short version
A peptide discussed in research on immune-system signalling. Findings depend on the condition and study design.
What does the research tell us?
A result in a cell or an animal does not establish the same result in people. Read the study design, the measurements, and the limitations before drawing a conclusion.
What remains uncertain?
The research question, the formulation, and the population all matter. This page is a starting point for understanding the literature, not a complete assessment of benefits or risks.
Identity & technical details
For readers who want the reference details.
- Name
- Thymosin Alpha-1
- Also known as
- Tα1, Thymalfasin
- Topic
- Immunity & cellular biology
- CAS
- 62304-98-7
- Amino-acid sequence
- SDAAVDTSSEITTKDLKEKKEVVEEAEN
Explore the sources
Open a source to read its methods and limitations. Published titles are kept in their original language.
In a mouse model of peritoneal metastases from colonic carcinoma, thymosin alpha-1 studied as an adjuvant to hyperthermic intraperitoneal chemotherapy was reported to be associated with a T-helper-1 immune response and increased CD8+ T-cell infiltration, while no direct anti-tumor effect of the peptide alone was observed.
In murine models of cystic-fibrosis-related gut inflammation, thymosin alpha-1 was reported to be associated with restored intestinal barrier integrity and immune homeostasis, with anti-inflammatory effects extending to the pancreas and liver.
This review surveys the reported immunomodulatory properties of thymosin alpha-1 across the literature, summarizing proposed mechanisms involving T-cell maturation and innate immune signaling as described in preclinical and clinical reports.
This guide explains research. It does not recommend a treatment, product, or dose.
A laboratory arithmetic tool. It does not determine a dose for a person.
Peptidoteca is part of the same business portfolio as ReadyPep. Commercial relationships should be considered when reading our content.
ReadyPep · Research supplies ↗