In rat brain neuron preparations, the peptide Semax (an ACTH(4-10) analogue) was reported to influence intracellular calcium dynamics, increasing the frequency of spontaneous calcium fluctuations in pyramidal-layer neurons. Findings are limited to an ex-vivo/in-vitro rodent model.
Semax
A short synthetic peptide discussed in research on brain signalling and responses to stress or injury.
The short version
A short synthetic peptide discussed in research on brain signalling and responses to stress or injury.
What does the research tell us?
A result in a cell or an animal does not establish the same result in people. Read the study design, the measurements, and the limitations before drawing a conclusion.
What remains uncertain?
The research question, the formulation, and the population all matter. This page is a starting point for understanding the literature, not a complete assessment of benefits or risks.
Identity & technical details
For readers who want the reference details.
- Name
- Semax
- Topic
- Brain & hormones
- CAS
- 80714-61-0
- Amino-acid sequence
- MEHFPGP
Explore the sources
Open a source to read its methods and limitations. Published titles are kept in their original language.
In a female mouse spinal-cord-injury model, the peptide Semax was reported to target the μ-opioid receptor gene Oprm1, promoting its deubiquitination, and was associated with functional recovery in the injured animals.
In a male rat model of chronic unpredictable stress, the ACTH(4-10) synthetic analog Semax was reported to produce antidepressant-like and antistress effects, attenuating stress-induced anhedonia and associated markers of chronic stress load.
This narrative review of bioactive peptides in neurodegenerative disorders names Semax among example peptides discussed for reported roles in modulating oxidative stress, neuroinflammation, mitochondrial preservation, and synaptic plasticity in preclinical models, surveying proposed mechanisms rather than presenting primary data on Semax.
This guide explains research. It does not recommend a treatment, product, or dose.
A laboratory arithmetic tool. It does not determine a dose for a person.
Peptidoteca is part of the same business portfolio as ReadyPep. Commercial relationships should be considered when reading our content.
ReadyPep · Research supplies ↗