Using in-vitro incubations and rat samples, this analytical study describes a UHPLC-Q-Exactive orbitrap MS/MS method for the simultaneous quantification of TB-500 and its metabolites, and reports in-vitro screening of associated wound-healing activities.
TB-500
A compound related to thymosin beta-4, discussed in research on cell movement and tissue repair.
The short version
A compound related to thymosin beta-4, discussed in research on cell movement and tissue repair.
What does the research tell us?
A result in a cell or an animal does not establish the same result in people. Read the study design, the measurements, and the limitations before drawing a conclusion.
What remains uncertain?
The research question, the formulation, and the population all matter. This page is a starting point for understanding the literature, not a complete assessment of benefits or risks.
Identity & technical details
For readers who want the reference details.
- Name
- TB-500
- Also known as
- Thymosin Beta-4 fragment, TB4
- Topic
- Recovery & skin
- CAS
- 885340-08-9
- Amino-acid sequence
- LKKTETQEKNPLPSKETIEQEKQAGES
Explore the sources
Open a source to read its methods and limitations. Published titles are kept in their original language.
In a mouse model of Pseudomonas aeruginosa-induced bacterial keratitis, with in-vitro validation in LPS-stimulated murine RAW 264.7 cells, the study reports that thymosin beta-4 (Tβ4) was associated with activation of pro-resolving inflammatory pathways during the resolution of infection and inflammation. Findings are limited to animal and cell-culture models.
In a mouse wound-healing model with in-vitro binding assays, Thymosin β4 (TB4/TB-500)-loaded soluble microneedles were associated with enhanced wound closure, an effect the authors attribute to specific binding to the downregulated immune regulators Vsig4 and IL22rα2. These are preclinical (rodent and in-vitro) findings only.
This review synthesizes reported mechanisms of thymosin beta-4 (the peptide also known as TB-500), including actin regulation and anti-inflammatory signaling, as described across preclinical models of acute and chronic kidney injury.
This guide explains research. It does not recommend a treatment, product, or dose.
A laboratory arithmetic tool. It does not determine a dose for a person.
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